C:\Program Files (derogatory)\
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av by @AviYinglet
C:\Program Files (derogatory)\
This is actually funny and I don't know why
(Please tell me (which will ruin the joke) but I'll actually know and (recursion))
it's a combination of Program Files {x86}, the directory in which 32-bit programs will install to in 64-bit Windows, and the use of (derogatory) to indicate that the thing tagged is meant to be read in a derogatory tone (though it's often used in a more lighthearted or joking manner).