Edit: See this post for an update (tl;dr it probably wasn't the bicalutamide, though I have reason to suspect it's actually kicking in as of 3/13/2023)
I don't know how long it takes for bicalutamide to start blocking T, but I took my first dose of it around 8pm and already by 11pm it seems to have had me feeling some kinda way, and now at 5:30am1 I genuinely feel better than I have in... basically as long as I can remember? Like, not in the normal gender euphoria way where I'm giddy about a specific thing (like feeling cute, having someone affirm my gender in certain ways, fantasizing about being involved in some hypothetical romantic scenario with someone who sees me as a girl in a specifically gay way, etc.) but instead in just a kind of passive way, like wearing particularly comfy clothes after wearing an itchy sweater or something. Is... is this what it's like not having weak gender dysphoria as constant background noise in your head??? I'm sure I must have felt like this at some point in my life, but I don't think even things like mood stabilizers, antidepressants, etc. have had this kind of impact2 on me. I've considered that it might just be one of those placebo things (specifically the kind where a medication feels like it's working before it's actually had time to start working3), but even if it is, I was not expecting to feel this good, and especially not this fast. 
Notes:
- If you know me, then you already know my sleep schedule is fucked to shit. That 8pm dose? That was with what was essentially my breakfast. (To be fair, my sleep schedule is mostly only a problem in the sense that the world seems uninterested in accomodating night owls like myself)
- Though to be fair I'm awful at remembering these kinds of ambient mood shifts - my mood tends very much color my perception of past events, which unfortunately makes it particularly unreliable when trying to recall how I felt during a particular period of my life relative to how I feel in the present. I can more or less remember how a specific event made me feel, but even then that's still viewed through the lens of my current mood.
- I'll admit I'm actually not even 100% bicalutamide is supposed to do this in the first place. I'm going off the understanding that having the wrong sex hormones pumped into your brain can cause biochemical gender dysphoria independent of any physical features, which I'm fairly certain is the case (at least, based on the unfortunate case of David Reimer (warning, that page contains some pretty dark descriptions of child abuse, suicide, etc., not exactly a happy read))
