Dissatisfied with the existing template I'd found long ago (probably on KnowYourMeme) that was low-resolution and built from cropped versions of the movie frames for some reason, I borrowed the Blu-Ray of “Despicable Me” from the library so I could make a proper version.

Each of the frames is straight from the Blu-Ray rip, not scaled at all. Arrayed two-by-two, and with a black background to fill out the aspect ratio difference*, they fit into a 4K image perfectly.

This image is a PNG, to further minimize quality loss before you add your own elements of Gru's plan and export as JPEG.

*The movie's actual footprint is 1920 by 1040, so 40 pixels less-tall from the standard 1080.