I don't know if there's ever been something that's made me give up on 100%ing a game as quickly as the inclusion of Jacob and Esau in The Binding of Isaac.
I've made significantly more progress with Tainted Lost (the character that dies in one hit with no rechargable shield) than Jacob and Esau, to give you an idea of just how much I fuckin' hate playing them. Very telling that every guide on playing them effectively is just "IDK man, try to keep them together I guess"