Under appreciated thing I love about the Nemesis System is how it mechanizes a bond of intimacy with disgust. I lot of stories about companionship have this conservative tendency to argue the worst thing you can do to another person is hold a grudge. The implicit idea being “if only you got to know them better” you could move past conflict. Its a bit rich in stories where violent conflict is the draw, how cool is the combat etc. Nemesis trades that for bare nihilism and ironically more emotional honesty. If it were used in a game without eugenics baked into its inspiration you could really do something impressive.