thinking about the PROTOTYPE series and what i'd do with it were i given a creative director role for a third game (or a reboot, idk the end of the second one seemed somewhat definitive)
i think one thing i'd do is character customization but in the form of like. you're recombining traits from those you've consumed. so besides just straight up the form of someone you've gotten, for the first little while in the game your custom forms are very firmly in the uncanny valley because you're not exactly practiced at making new faces yet.
overall i'd lean much more on the "you are a monster created by a horrible corporation full of even more monstrous people" angle. like the shit you do isn't good, you're not a hero, but the people you're going out of your way to harm are so, so much worse.