Just had a fun build in Peglin where I got the Glorious Sufferring and the Matryoshka. Which means all my orbs get -6/-6, leaving most a 0/2. But! They all multiball and upgrade every peg hit with a +4. So first shot - hit about half the board, do 0 damage. Second shot - refresh and hit about half again, do several hundred damage.
Toss in some refresh and heal effects on top and that's how I got through Cruciball 13.