Mega Man 3 (USA).nes: 26F39 = 00
You can find out what that does for yourself.
comments
The address assumes a ROM that still has the 16-byte header. It's a ROM, after all.
I'm not spoiling what the surprise is — you have to see what it does yourself!
I'll just say that it took longer than I had expected to find the right byte to modify. The other ones would have been a lot easier...
cp "Mega Man 3 (USA).nes" mm3hack.nes
dd conv=notrunc of=mm3hack.nes if=/dev/zero bs=1 count=1 seek=159545
(and then to open in your system's default NES emulator: xdg-open mm3hack.nes)
non-unix users may have to install unix first

