Fun story idea I had at work, taking place Post-Omenpath (Maybe you include the sleeping curse maybe you don't up to you), where an Eldraine based party encounters a group of Werefolk are plotting to conquer the realm, because it turns out malicious Howlpacks of werewolves from Innistrad have made their way to the plane via Omenpath. They believe with the foreign magic of Eldraine, werefolk can craft a curse to make all the peoples of Eldraine of one lycanthropic kin.
Maybe the players have to defeat the Howlpack Alphas and it turns out this is all the machinations of some Fae or a coven of witches or something!