Chubby cuddlebot Lemma!

this prompted me to look up Pondsmith's Cyberpunk working for it and from what he says about it in brief ( wiki and blurb about it towards the bottom https://cyberpunk.fandom.com/wiki/Cyberpsychosis ), his 'framework' for what it is... he used anabolic steroid addiction (or more pointedly: "roid rage") as the inspiration for it..
Y'know the whole "some who use it too much may potentially lose their shit", that kinda thing.
Much to CDPR's 'credit' they seemed to keep instances of 'cyberpsychos' to those with some variety of mental trauma, or disorder. Mainly drug addicts, PTSD (lotta war vets it'd seem) or just plain psychopaths.

In Adam Smasher's case.. whom is mostly just a sparse bit of meat and skin among all that hardware, i'm fairly sure he was just plain psychotic to begin with.

The anime did a shit poor interpretation of it too, which didn't help. A big part of a setting needs more indepth explanation beyond "sometimes people just can't handle all that hardware, but some can.."
There's also a immunosupressant (immuno-blockers they call them), so i dunno.

Personally: i think people can handle tech better than that.

That's my bead on it anyway, not great, not terrible, just... eh.
As far as i can think of: infection + nerve damage + mental trauma whether drug induced or other factor = some sort of disassociation of heavily augmented human, fight or flight takes over and havoc ensues.

Cyberpsychosis as something produced by a bunch of conflicting DRM is something I'm suprised we don't see more often as it's much more fitting to the concept of cyberpunk than "having a robot arm = you're a monster". The idea that shitty corporations who couldn't give a fuck about how their mods work with mods from other companies end up hurting people probably exists right now to some extent.

I think I've already said this but if you ever do get a game goin' hit me up 👀

Yeah the genre of cyberpunk TTRPGS has always been full of ableist gross stuff like that. I'm glad that more and more independent devs are getting known and their systems explored that aren't written from the scope of cis-heteronormativity.