HC New Game makes R4make an action/survival-horror game where your back is always against the wall, trying desperately to eke out any advantage you can get while the world holds the resources you need just out of reach.
Playing Standard NG+ immediately afterward makes the game an interventionist power fantasy where Leon S. Kennedy, Verdugo of the UN, descends upon a rural European community to bring the wrath of the IMF upon the peasantry.