While Gex is undoubtedly the killer app for the 3DO, PO'ed is a close second! As a bonus, this version doesn't suffer from the awful texture warping of the Playstation port, at the cost of running worse overall IIRC.
Source: Next Generation 12 (December 1995)
Scan source: RetroMags
This, along with PO'ed, were what made me morbidly curious about the 3DO as a wee child. Something about the gross-out edginess made games like this (and the systems they were being sold on) seem so much more "mature" or adult to my childhood mind.
While I would later play PO'ed (surprisingly solid!), I don't believe I've ever tried Cyberdillo. It's not even the bad reviews that have kept me from playing it, either, but the billion other obscure retrogames demanding my time.