A game where each PC has a straight-forward goal (eg: "get a good night's sleep," "make it home for my mother's birthday," "pay the bookie before they kill my cousin"), but is faced with escalating obstructions. The winds of fate conspire against us, etc etc. Best handled as a mini-campaign, 3–5 episodes.
*Actually modeled on Scorsese's After Hours, but that doesn't make for as nice a title
The more I think about this, the more I like it. But as mentioned in the previous post, I think explicitly modeling it on After Hours is the better approach — pegging it to a particular city/set of locations, keeping the stakes comically low ("I just need to get uptown"), and the obstacles absurdly heightened ("this neighborhood has mistaken me for who??").
Setting aside the mechanics, which are maybe just a dialed-up version of "succeed, but with complication" dice rolls, I wonder if it works best as a tightly packaged system + setting. Generating obstacles that play off one another in increasingly claustrophobic ways is a lot to ask of a GM.