It's honestly surprising to me that nobody seems to have successfully released a metroidvania roguelike yet... as in, a game where there's a randomly generated map with a randomly generated solvable network of locks and keys, but the locks and keys are affordances you can collect.
Or, if you prefer, a metroidvania where the 'randomizer mod' is both built-in and the default way to play the game.
I'm not insane, right? Randomizer mods are popular, and have been popular for years. Especially with streamers. It feels like a game designed around this style of play should be a niche someone was trying to occupy!