Concept: A logistics-em-up in the vein of Factorio or Satisfactory, except with a biopunk aesthetic; all of your 'machines' are purpose-grown organs that you're stringing together into a giant factory-animal. Instead of conveyor belts you have intestine-like tubes moving inputs and outputs around through peristaltic motion, etc.
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in reply to @bruno's post:
Atrio is a little like this, but not quite as grisly as I think you're imagining
one of the sub games in Last Call BBS, "The Forbidden Path", sort of has this going on, as you're trying to assemble masses of flesh and bone by following a series of growth steps and rules for it to turn out right
Level 5 cilia unlocked
Alert! Intestinal tract is constipated!
Bladder construction completed
Alert! Bile levels are critical!