From my lived experiences, I think that TF "victims" would eventually forget what it feels like to be human. They may still desire to go back, but I think the longer they spend in their new forms, the less they'll know what it entails to go back.
I mostly say that because of all the changes I've gone through. Whether they voluntary or not, good or bad, I don't really remember what my life was like before they happened. I don't remember what my body felt like before I transitioned. Nor do I remember what it was like before I got disabled (excluding the disability I've had basically since birth, of course).
They're just things I live with. Do I wish some of these things would go away? Of course! But I do not know what that would actually feel like even if I have experienced it before.
Basically I just love some loss of humanity in transformation x3