Trump being knocked off the ballot in Colorado is not especially significant, especially pending Supreme Court review (spoilers, they'll rule that he has to be convicted first)
Having said that, there are ways in which this could spiral and further complicate his campaign. If more states successfully bring cases such as this and he IS eventually convicted, he's done. Also, it's going to put even more swing voters off of his ticket.
Not the end of the nightmare, but a good night regardless.