once you make too many layers, that file will just start slowing down and eventually it just runs out of memory and crashes without any warning. constantly. if you're unlucky this also corrupts the layer you were working on.
it creates automatic rollback points (when? how? unclear) so you can revert to an earlier version, and also i have the habit of meticulously duplicating files as i am working on them (i'm EXTREMELY thankful for Blender's "incremental save" feature), but it still sucks
another thing thats very very annoying is how buggy canvas resizes are; sometimes when you increase the canvas size, the existing layers will move around on the canvas and misalign??? this can then also start happening on an image which previously had its canvas scaled up, any time while selecting multiple layers and transposing them, or randomly when the app crashes. IT SUCKS.
all in all, i think i'll wind down my IP usage and instead shift to clip studio paint on android (which i was already using on desktop anyway). the main thing that sucks is that i'll have to remake/find an equivalent for my main lineart brush that i was really happy with

