(I just noticed that @cofruitrigus did basically this exact post almost a month before I did.)
It's interesting that there's an internet meme about someone being "the only human" in a Muppet movie, when there is no theatrical Muppet movie where that's the case. It's the norm on The Muppet Show for the guest to be the only human on-screen1, but Muppet films fall into two categories:
- The Muppets exist in a metafictional human world, usually as performers playing performers in a normal human world where they are the only puppets2:
- The Muppet Movie
- The Great Muppet Caper (not performers, but a bunch of fourth-wall breaking)
- The Muppets Take Manhattan
- Muppets from Space
- The Muppets
- Muppets Most Wanted (haven't seen it yet, but it's a direct sequel to The Muppets)
- The Muppets interpret a classic story, with multiple humans playing pivotal roles:
- The Muppet Christmas Carol (the Scrooge family and their partners are human)
- Muppet Treasure Island (Jim Hawkins, Long John Silver, Billy Bones, and Mrs. Bleveridge are human)
- The Muppets' Wizard of Oz (TV movie; Dorothy, Uncle Henry, Aunt Em, and every other Kansas resident are human except Toto, who is a non-Muppet prawn until entering Oz)
I find it provocative that our cultural imagination has the Muppets living in a puppet world with a single visiting human, while the works are much more often about the Muppets struggling to exist in a world that is not meant for them.
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Even on The Muppet Show, the Muppet Theater clearly exists in our pop-cultural world, where other humans exist in the world outside.
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Sometimes there are Muppets who are not with the main group of The Muppets. Bobo the Bear appears multiple times as the stooge of a villain.