Trying to make moral dichotomies out of "respecting" or "defying" (nature/God/&c.) inherently misses the point, because the mere act of wearing an N95 mask or taking exogenous insulin is an act of defiance β as is building a shoddy freeway in a manner that guarantees it's going to get washed out in floods a few times a century.
Sometimes, it's best to not try to "control" forces that don't need us to control them, and which'll hit us back ten times as hard if we do try to control them. Other times, it is an atrocity in and of itself to adopt some kind of moral stance against that sort of "arrogance".

