(yes, this also works on mobile)
There's currently an issue where deeply-nested comment threads squish up against the box edge and become unreadable, as detailed in this bug report. This got me thinking about alternative designs until I came up with something I liked and decided to implement.
This script flattens replies down to one indent level and collapses them behind a click-through. If a reply isn't directly responding to the one above it, then a quote is embedded with a clickable link to the comment it's replying to.
If you have Tampermonkey, then click here to install this userscript. You can also view the source code here.