Hybrid, by Selur (Georg Pelz), is an application for doing nearly anything to and with video. It picks up where Handbrake leaves off, and wraps around more than just a select number of encoders; upwards of 100 executables from various tools and toolkits that are included in its installation folder. It can encode, filter, mux/demux/remux to and from a number of container formats, crop, scale, and much more.
Every single option of each of these tools is broken out into a tabbed GUI. Most of them include documentation text on mouseover.
It can read and encode an extremely wide variety of video codecs; the user can encode anything ranging from H.264 to ProRes, AV1, or UT Video lossless. It includes dozens of filters from FFMpeg, Avisynth, and Vapoursynth; each filter has its own tab of options to explore.
Of note is its extensively customizable deinterlacing support. This is extremely useful when dealing with interlaced video captured from analog sources. It makes it easy to configure Vapoursynth's deinterlace and detelecine filters: Yadifmod, QTGMC, VIVTC, TDeintMod, Bwdif, or TIVTC.
A single Hybrid job will automatically chain together whatever tools are required to take the video file from start to finish. The generated command line for each tool is provided; jobs can be queued. Hybrid can be an entire workflow on its own, or integrated into your existing workflow.
Hybrid is closed source, and is freeware. (Its included dependencies are distributed under a variety of licenses.) Download here.