Doom Infinite is a roguelike mod for Doom 2 on GZDoom that gives it a gameplay loop similar to Risk of Rain 2. I've been pretty hooked on it.
I did another run later on with an unstoppable combo. An item that gives you one point of armor every second + an item that disables armor but converts all armor to health + an item that matches your attack stat to your health. So essentially I gained 1 HP and 1 attack point every second. Constantly at 999 health, constantly at 999 attack so everything died in one hit so nothing could drop my health.
Unfortunately I ran into the Alpha Risk of Rain 2 problem--it seems I was so powerful, the game couldn't spawn any enemies to match me, and therefore didn't spawn anything. I had no choice but to end the game myself. I love it. Best Doom mod on the web right now.