One more thought about the note Desolation plays: I really like that John briefly takes his disguise off for this page. I think it works really well as an encapsulation of what this page, Homestuck’s title page, represents.
Homestuck is a deeply silly series. It also goes to some genuinely heart-wrenching emotional places and isn’t afraid to intertwine its silliness with seriousness when it needs to. However, the first 81 pages of Homestuck are more or less exclusively silly. The plot hasn’t properly started yet. It’s just John dicking around in his room and trying to get his hands on a video game as the readers make suggestions for what he does. It’s jokes!
It’s just jokes, but the whole time, once you’re looking back having read further in, you know that there’s a story about the end of the world lurking in the wings and waiting to start at any moment. And this page serves as our first little glimpse of that.