Everything, by Voidtools (David Carpenter), directly parses the NTFS Master File Table, allowing it to index drives quickly and search them near-instantly. Search queries can be formulated with a wide variety of operators to find exactly the file needed.
Everything is much faster than Windows Search; it supports NTFS, FAT, network drives, and more; and it allows extensive customization of the UI and functionality, with plenty of power user features. Everything version 1.5, currently in alpha, will allow use and indexing of the Windows Property System for instant search of all file metadata known to the OS, along with many other improvements.
It is closed source, and is freeware. Download here.
I have absolutely no consistent file organisation and with the power of Everything it's literally just not a problem. I can just find files now. Also it searches all of the windows appData folders so it works for finding game save locations like 70% of the time which always makes me feel like a wizard