but now I'm researching sassafras. The internet can't decide if the FDA banned it's us in mass-produced foods/drugs in 1960 or 1976 but it's been banned none the less.
Allegedly because an absolute shit ton of safrole, a chemical in the roots used for a bunch of stuff, can make you develop tumors in your liver, but to give you an idea of the lab conditions they used to replicate this in rats: they dosed, at 50mg/kg. Now if you're 150lb that's ~68kg. That's 3,402mg per day, or 340, 10mg tablets if both of these calculators are right. That's a fuck ton of anything to take. It may surprise you that the second test, where they slowly raised from 0.6 to 750 mg/kg of safrole over the course of 48 hours, also went poorly for the rat.
The most important take away from all this is this: sassafras is also a precursor to MDMA.
It's still allowed to be used for some things like Creole gumbo I believe but like, I'm sure buying a fuck ton of it get's the ABC's on your ass real quick.